Endocrine Abstracts

Introduction: Uterine myomas are the most frequent benign uterine tumours of smooth muscle cells of myometrium. Myoma is the most common uterine tumours occurring in 20–30% of women during their reproductive years. Despite this common complication of benign tumours, in most cases there are barrier of natural fertility and pregnancy continuing. Therefore, to understanding better the genetic characteristics of myoma help us in the treatment and preventive measures in these ...

Limited research has been conducted on adrenal gland as target of endocrine disrupting chemicals (EDCs). Moreover, studies on steroidogenesis as the target of EDCs has also attracted lesser attention compared to other metabolic pathways. We studied the effects of two extensively used phthalate esters viz., di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP) on the adrenal gland in Wistar rats and checked its susceptibility against the exposure of these extensively use...

Introduction: Hyperthyroidism is a prevalent condition which affects approximately 2% of the female population and 0.2% of the male population in the UK. 75% of cases are caused by the auto-immune condition, Graves’ disease. Thyrotropin receptor antibodies (TRAb) are raised in 90% of patients with Graves’ disease and are commonly used to investigate the aetiology of thyrotoxicosis.Background: TRAb can be used to confirm Graves’ disease due...

Background: The University Teaching Hospital Trust has a regional neuroendocrine tumour (NET) service that requires a database exclusively for NET patient information. UK and Ireland NET Society (UKINETS) guidelines for gastroenteropancreatic (GEP) NETs recommend plasma Chromogranin-A (Cg-A) and 24 h urinary 5-hydroxyindoacetic acid (24 h Ur 5-HIAA) as baseline investigations. This audit investigated both guideline adherence and the value of these tests in making the diagnosis...

This study aimed to determine if berberine (BBR) or pioglitazone (PGZ) is more effective and safer for treating people with type 2 diabetes or non-alcoholic fatty liver disease (NAFLD). 184 people with NAFLD and impaired glucose metabolism were randomly allocated 16 weeks of lifestyle intervention (LI), LI plus PGZ (15mg daily) or LI plus BBR (1.5 g daily) as their course of treatment. We measured the levels of blood insulin, osteocalcin, C reactive protein (CRP), liver enzyme...

In this study, effects of bovine somatotropin on libido, serum testosterone, hematological indices and certain serum biochemical metabolites in Sahiwal bulls were investigated. Six adult Sahiwal bulls with clinically normal reproductive tract and kept at the Semen Production Unit, Qadirabad, Sahiwal, Pakistan were used. These bulls were divided into two equal groups, i.e. treatment and control. Bulls of the treatment group were given bovine somatotropin (bST) at of 500 mg week...

Background: Wide range of biochemical and hematological laboratory values changed during diabetic pregnancy comparable to physiological pregnancies. hyperglycemia is a risk factor for fetal macrosomia. The level of maternal triglycerides have been strongly correlated with excess fetal growth and large for gestational age.Aim of the study: The aim of this study is to evaluate the effect of maternal hyperglycemia and triglycerides on pregnancy outcome in d...

Introduction: Pituitary apoplexy is a rare clinical syndrome secondary to abrupt haemorrhage or infarction of the pituitary gland. It complicates 2-12% of pituitary tumour, most commonly in the setting of non-functioning adenomas 1. We are reporting a case on the evolving apoplexy. A 28-year-old male with sudden onset stabbing type frontal headache at night. He described this as the worst headache in his life. CT scan of head at presentation showed a 1.9 m lesion in the pituit...

Hyperthyroidism is associated with multiple gastrointestinal (GI) symptoms including vomiting, although this is not very common. We present a case of a 61-year-old female patient, who was admitted under surgeons with persistent and severe vomiting which was very difficult to manage. No acute surgical cause for vomiting was found and the patient was referred for a gastroscopy which was normal. Her past history was significant for Grave’s disease which was in ...

Hyperthyroidism is associated with multiple gastrointestinal (GI) symptoms including vomiting, although this is not very common. We present a case of a 61-year-old female patient, who was admitted under surgeons with persistent and severe vomiting which was very difficult to manage. No acute surgical cause for vomiting was found and the patient was referred for a gastroscopy which was normal. Her past history was significant for Grave’s disease which was in ...